Nanoparticle (NP)-based drug-delivery systems are frequently employed to improve the intravenous administration of chemotherapy; however, few reports explore their application as an intraperitoneal therapy. We developed a pH-responsive expansile nanoparticle (eNP) specifically designed to leverage the intraperitoneal route of administration to treat intraperitoneal malignancies, such as mesothelioma, ovarian, and pancreatic… Continue reading…
Several drug leads isolated from our fungal library and that at Mycosynthetix are showing promising activity in vivo. One of these is a compound that was isolated from the beautiful red droplets produced by an endophytic fungus, Penicillium restrictum. As described in a recent high profile article in Antimicrobial Agents… Continue reading…
Clinical studies to understand how dietary supplements alter drug metabolism The Center of Excellence for Drug Interaction Research (NaPDI) provides leadership on how best to study potential adverse interactions between plant-based natural products (herbal medicines) and conventional medications. The center is composed of a uniquely experienced and multidisciplinary team, led… Continue reading…
The Department of Biology and the Department of Chemistry and Biochemistry at UNCG have been selected to participate in the CUR Transformations Project, an NSF-supported project of the Council of Undergraduate Research. The UNCG project is titled “A Collaborative Proposal Between Chemistry and Biology to Scaffold Undergraduate Research Across the… Continue reading…
Our laboratory specializes in metabolomics and small molecule mass spectrometry. We provide quantitative LC-MS, fragmentation (MS-MS or MSn), GC-MS and MALDI-TOF-TOF MS analysis. The laboratory was created to provide mass spectrometry analysis and training to the UNC Greensboro Chemistry and Biochemistry Department, UNCG campus community, and the surrounding Piedmont Triad… Continue reading…
This past summer, I had the opportunity to participate in a 3 month summer internship at Procter & Gamble in Mason, OH. It was the fastest, most exhausting, and yet most rewarding summer of graduate school. Not only did P&G assist in my relocation, they had numerous networking opportunities for… Continue reading…
Photodynamic therapy (PDT) is a strategy for treating cancer, where a nontoxic prodrug, the photosensitizer (PS), is activated by light to form reactive species that destroy tumor tissue. The advantage of PDT over traditional chemotherapy is that drug toxicity can be localized to the target region through precise spatial and… Continue reading…
Each year 200 girls from local middle and high schools gather at the UNCG campus to participate in “Triad Tech Savvy Girls”. This free event, sponsored by the American Association of University Women and the University of North Carolina Greensboro, is a herculean effort that includes over 100 volunteers. Girls… Continue reading…
