Publications

Targeted and untargeted analysis of secondary metabolites to monitor growth and quorum sensing inhibition for methicillin-resistant Staphylococcus aureus (MRSA)

Derick D. Jones Jr., Lindsay K. Caesar, Chantal V. Pelzer, William J. Crandall, Christian Jenul, Daniel A. Todd, Alexander R. Horswill, Nadja B. Cech

Journal of Microbiological Methods, Epub 2020 July 7.

PMID: 32649968, doi: 10.1016/j.mimet.2020.106000

Chemical evaluation of the effects of storage conditions on the botanical goldenseal using marker-based and metabolomics approaches

Manead Khin, Nadja B. Cech, Joshua J. Kellogg, Lindsay K. Caesar

The Yale Journal of Biology and Medicine, 2020, 93(2), 265-275.

PMID: 32607087, PMCID: PMC7309669

The Chemistry of kratom [Mitragyna speciosa]: updated characterization data and methods to elucidate indole and oxindole alkaloids

Laura Flores-Bocanegra, Huzefa A. Raja, Tyler N. Graf, Mario Augustinović, E. Diane Wallace, Shabnam Hematian, Joshua J. Kellogg, Daniel A. Todd, Nadja B. Cech, Nicholas H. Oberlies

Journal of Natural Products, 2020, 83(7), 2165-2177.

PMID: 32597657, doi: 10.1021/acs.jnatprod.0c00257

Identification of adulteration in botanical samples with untargeted metabolomics

E. Diane Wallace, Daniel A. Todd, James M. Harnly, Nadja B. Cech, Joshua J. Kellogg 

Analytical and Bioanalytical Chemistry, 2020, 412(18), 4273-4286.

PMID: 32347364, PMCID: PMC7321857, doi: 10.1007/s00216-020-02678-6

Processing, export, and identification of novel linear peptides from Staphylococcus aureus.

Katrin Schilcher, Lindsay K. Caesar, Nadja B. Cech, Alexander R. Horswill.

mBio, 2020, 11 (2), e00112-20.

PMID: 32291297, PMCID: PMC7157817, doi: 10.1128/mBio.00112-20

Novel peptide from commensal Staphylococcus simulans blocks MRSA quorum sensing and protects host skin from damage.

Morgan M. Brown, Jakub M. Kwiecinski, Luis Mejia Cruz, Ali Shahbandi, Daniel A. Todd, Nadja B. Cech, Alexander R. Horswill.

Antimicrobial Agents and Chemotherapy, 2020, 64(6), e00172-20.

PMID: 32253213, PMCID: PMC7269516, doi: 10.1128/AAC.00172-20

Composite score analysis for unsupervised comparison and network visualization of metabolomics data.

Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech.

Analytica Chimica Acta, 2020, 1095, 38-47.

PMID: 31864629, PMCID: PMC6948848, doi: 10.1016/j.aca.2019.10.029

Selection and characterization of botanical natural products for research studies: a NaPDI Center recommended approach.

Joshua J. Kellogg, Mary F. Paine, Jeannine S. McCune, Nicholas H. Oberlies, Nadja B. Cech.

Natural Product Reports, 2019, 36 (8), 1196-1221

PMID: 30681109, PMCID: PMC6658353,  doi: 10.1039/c8np00065d

Mycopyranone: a 8,8′-binaphthopyranone with potent anti-MRSA activity from the fungus Phialemoniopsis sp.

José Rivera-Chávez, Lindsay K. Caesar, Juan J. Garcia-Salazar, Huzefa A. Raja, Nadja B. Cech, Cedric J. Pearce, Nicholas H. Oberlies.

Tetrahedron Letters, 2019, 60 (8), 594-597

PMID: 31598014, PMCID: PMC6785197, doi: 10.1016/j.tetlet.2019.01.029

Simplify: A mass spectrometry metabolomics approach to identify additives and synergists from complex mixtures.

Lindsay K. Caesar, Sabina Nogo, Cassandra N. Naphen, Nadja B. Cech.

Analytical Chemistry, 2019, 91 (17), 11297-11305

PMID: 31365233, PMCID: PMC6817979, doi: 10.1021/acs.analchem.9b02377

Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2.

Lindsay K. Caesar and Nadja B. Cech.

Natural Products Report, 2019, 36(6), 869-888

PMID: 31187844, PMCID: PMC6820002, doi: 10.1039/c9np00011a

Apicidin attenuates MRSA virulence through quorum-sensing inhibition and enhanced host defense.

Corey P. Parlet, Jeffrey S. Kavanaugh, Heidi A. Crosby, Huzefa A. Raja, Tamam El-Elimat, Daniel A. Todd, Cedric J. Pearce, Nadja B. Cech, Nicholas H. Oberlies, Alexander R. Horswill.

Cell Reports, 2019, 27(1), 187-198.e6

PMID: 30943400, doi: 10.1016/j.celrep.2019.03.018

Quorum sensing between bacterial species on the skin protects against epidermal injury and atopic dermatitis.

Michael R. Williams, Stephen K. Costa, Livia S. Zaramela, Shadi Khalil, Daniel A. Todd, Heather L. Winter, James A. Sanford, Alan M. O’Neill, Marc C. Liggins, Teruaki Nakatsuji, Nadja B. Cech, Ambrose L. Cheung, Karsten Zengler, Alexander R. Horswill, Richard L. Gallo.

Science Translational Medicine, 2019, 11(490)

PMID: 31043573, doi: 10.1126/scitranslmed.aat8329

Mapping the fungal battlefield: Using in situ chemistry and deletion mutants to monitor interspecific chemical interactions between fungi.

Sonja L. Knowles, Huzefa A. Raja, Allison J. Wright, Ann Marie L. Lee, Lindsay K. Caesar, Nadja B. Cech, Matthew E. Mead, Jacob L. Steenwyk, Laure N. A. Ries, Gustavo H. Goldman, Antonis Rokas, Nicholas H. Oberlies.

Frontiers in Microbiology, 2019, 10, 285.

PMID: 30837981, PMCID: PMC6389630, doi: 10.3389/fmicb.2019.00285

MroQ is a novel Abi-domain protein that influences virulence gene expression in Staphylococcus aureus via modulation of Agr activity.

Stephanie Marroquin, Brittney Gimza, Brooke Tomlinson, Michelle Stein, Andrew Frey, Rebecca A. Keogh, Rachel Zapf, Daniel A. Todd, Nadja B. Cech, Ronan K. Carroll, Lindsey N. Shaw.

Infection and Immunity, 2019, 87 (5)

PMID: 30833335, PMCID: PMC6479029, doi: 10.1128/iai.00002-19

Prenylated diresorcinols inhibit bacterial quorum sensing.

Noemi D. Paguigan, José Rivera-Chávez, Justin J. Stempin, Mario Augustinović, Aleksandra I. Noras, Huzefa A. Raja, Daniel A. Todd, Kathleen D. Triplett, Cynthia Day, Mario Figueroa, Pamela R. Hall, Nadja B. Cech, Nicholas H. Oberlies.

Journal of Natural Products, 2019, 82(3), 550-558

PMID: 30730742, doi: 10.1021/acs.jnatprod.8b00925

Opportunities and limitations for untargeted mass spectrometry metabolomics to identify biologically active constituents in complex natural product mixtures.

Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech.

Journal of Natural Products, 2019, 82(3), 469-484

PMID: 30844279, doi: 10.1021/acs.jnatprod.9b00176

Selection and characterization of botanical natural products for research studies: a NaPDI Center recommended approach.

Joshua J. Kellogg, Mary F. Paine, Jeannine S. McCune, Nicholas H. Oberlies, Nadja B. Cech.

Natural Product Reports, 2019, 36(8), 1196-1221

PMID: 30681109, doi: 10.1039/c8np00065d

Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics.

Diane E. Wallace, Nicholas H. Oberlies, Nadja B. Cech, Joshua J. Kellogg.

Food and Chemical Toxicology, 2018, 120, 439-447.

PMID: 30031041, PMCID: PMC6434943, doi: 10.1016/j.fct.2018.07.033

Phytochemical analysis and antimicrobial efficacy of Macleaya cordata against extensively drug-resistant Staphylococcus aureus.

Manead M. Khin,  Alan M. Jones, Nadja B. Cech, Lindsay K. Caesar.

Natural Product Communications, 2018, 13, 1479-1483.

PMID: 31080542, PMCID: PMC6508602, doi: 10.1177/1934578X1801301117

Analytical methods for the study of bioactive compounds from medicinally used Echinacea species.

Renato Bruni, Virginia Brighenti, Lindsay K. Caesar, Davide Bertelli, Nadja B. Cech, Federica Pellati.

Journal of Pharmaceutical and Biomedical Analysis, 2018, 160, 443-477

PMID: 30142565, doi: 10.1016/j.jpba.2018.07.044

Integration of biochemometrics and molecular networking to identify antimicrobials in Angelica keiskei.

Lindsay K. Caesar, Joshua J. Kellogg, Olav M. Kvalheim, Richard A. Cech, Nadja B. Cech.

Planta Medica, 2018, 84, 721-728.

PMID: 29571174, PMCID: PMC6277903, doi: 10.1055/a-0590-5223

Hierarchical cluster analysis of technical replicates to identify interferents in untargeted mass spectrometry metabolomics.

Lindsay K. Caesar, Olav M. Kvalheim, Nadja B. Cech.

Analytica Chimica Acta, 2018, 1021, 69-77

PMID: 29681286, PMCID: PMC5917943, DOI: 10.1016/j.aca.2018.03.013

Identification of intestinal UDP-glucoronosyltransferase inhibitors of green tea (Camellia sinensis) using a biochemometric approach: Application to raloxifene as a test drug via in vitro to in vivo extrapolation.

Dan-Dan Tian, Joshua J. Kellogg, Neşe Okut, Nicholas H. Oberlies, Nadja B. Cech, Danny D. Shen, Jeannine S. McCune, Mary F. Paine.

Drug Metabolism and Disposition, 2018, 46, 552-560.

PMID: 29467215, PMCID: PMC5890833, doi: 10.1124/dmd.117.079491

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.

Travis V. Gulledge, Nicholas M. Collette, Emily Mackey, Stephanie E. Johnstone, Yasamin Moazami, Daniel A. Todd, Adam J. Moeser, Joshua G. Pierce, Nadja B. Cech, Scott M. Laster.

Journal of Ethnopharmacology, 2018, 212, 166-174

PMID: 29042288,  PMCID: PMC5818717, doi: 10.1016/j.jep.2017.10.012

Biochemometrics to identify synergists and additives from botanical medicines: A case study with Hydrastis canadensis (goldenseal).

Emily R. Britton, Joshua J. Kellogg, Olav M. Kvalheim, Nadja B. Cech.

Journal of Natural Products, 2018, 81, 484-493

PMID: 29091439, PMCID: PMC6251718, doi: 10.1021/acs.jnatprod.7b00654

Coagulase-negative staphylococcal strain prevents Staphylococcus aureus colonization and skin infection by blocking quorum sensing.

Alexandra E. Paharik, Corey P. Parlet, Nadjali Chung, Daniel A. Todd, Emilio I. Rodriguez, Michael J. Van Dyke, Nadja B. Cech, Alexander R. Horswill.

Cell Host & Microbe, 2017, 22 (6), 746-756.e5

PMID: 29199097, PMCID: PMC5897044, doi: 10.1016/j.chom.2017.11.001

Interspecific and intraspecific hybrid Epichloë species symbiotic with the North American native grass Poa alsodes.

Tatsiana Shymanovich, Nikki D. Charlton, Ashleigh M. Musso, Jonathan Scheerer, Nadja B. Cech, Stanley H. Faeth, Carolyn A. Young.

Mycologia, 2017, 109(3), 457-474

PMID: 28723242; doi: 10.1080/00275514.2017.1340779

Conventional and accelerated-solvent extractions of green tea (Camellia sinensis) for metabolomics-based chemometrics.

Joshua J. Kellogg, Diane E. Wallace, Tyler N. Graf, Nicholas H. Oberlies, Nadja B. Cech.

Journal of Pharmaceutical and Biomedical Analysis, 2017, 145, 604-610.

PMID: 28787673, PMCID: PMC5804813, doi: 10.1016/j.jpba.2017.07.027

Signal biosynthesis inhibition with ambuic acid as a strategy to target antibiotic-resistant infections.

Daniel A. Todd, Corey P. Parlet, Heidi A. Crosby, Cheryl L. Malone, Kristopher P. Heilmann, Alexander R. Horswill, Nadja B. Cech.

Antimicrobial Agents and Chemotherapy, 2017, 61 (8), e00263-17.

PMID: 28607020, PMCID: PMC5527603, doi: 10.1128/AAC.00263-17

Comparison of metabolomics approaches for evaluating the variability of complex botanical preparations: green tea (Camellia sinensis) as a case study.

Joshua J. Kellogg, Tyler N. Graf, Mary F. Paine, Jeannine S. McCune, Olav M. Kvalheim, Nicholas H. Oberlies, Nadja B. Cech.

Journal of Natural Products, 2017, 80 (5), 1457-1466.

PMID: 28453261, PMCID: PMC5469520, doi: 10.1021/acs.jnatprod.6b01156

Secondary metabolites from the leaves of goldenseal (Hydrastis canadensis).

Martha Leyte-Lugo, Emily R. Britton, Daniel H. Foil, Adam R. Brown, Daniel A. Todd, Jose Rivera Chavez, Nicholas H. Oberlies, Nadja B. Cech.

Phytochemistry Letters, 2017, 20, 54-60.

PMID: 28736584, PMCID: PMC5516942, doi: 10.1016/j.phytol.2017.03.012

qNMR for profiling the production of fungal secondary metabolites.

Wilson C. Brooks, Noemi D. Paguigan, Huzefa A. Raja, Franklin J. Moy, Nadja B. Cech, Cedric J. Pearce, Nicholas H. Oberlies.

Magnetic Resonance in Chemistry, 2016, 55 (7), 670-676.

PMID: 28024162, PMCID: PMC5459663, doi: 10.1002/mrc.4571

Antimicrobial fungal endophytes from the botanical medicine goldenseal (Hydrastis canadensis).

Joseph M. Egan, Amninder Kaur, Huzefa A. Raja, Joshua J. Kellogg, Nicholas H. Oberlies, Nadja B. Cech.

Phytochemistry Letters, 2016, 17, 219-225.

PMID: 28603575, PMCID: PMC5461979, doi: 10.1016/j.phytol.2016.07.031

Secondary metabolites from fungal endophytes of Echinacea purpurea suppress cytokine secretion by macrophage-type cells.

Amninder Kaur, Martina Oberhofer, Monika Juzumaite, Huzefa A. Raja, Travis V. Gulledge, Diana Kao, Stanley H. Faeth, Scott M. Laster, Nicholas H. Oberlies, Nadja B. Cech.

Natural Product Communications, 2016, 11 (8), 1143-1146.

PMID: 28479944, PMCID: PMC5414731

A review of the medicinal uses and pharmacology of ashitaba.

Lindsay K. Caesar and Nadja B. Cech.

Planta Medica, 2016, 82 (14), 1236-45.

PMID: 27399234, doi: 10.1055/s-0042-110496

Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition.

Daniel A. Todd, David. B. Zich, Keivan. A. Ettefagh, Jeffrey. S. Kavanaugh, Alex R. Horswill, Nadja B. Cech.

Journal of Microbiological Methods, 2016, 127, 89-94.

PMID: 27237773, PMCID: PMC5226215, DOI: 10.1016/j.mimet.2016.05.024

A validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts.

Tyler N. Graf, Nadja B. Cech, Stephen J. Polyak, Nicholas H. Oberlies.

Journal of Pharmaceutical and Biomedical Analysis, 2016, 126, 26-33.

PMID: 27136284, PMCID: PMC4893890, doi: 10.1016/j.jpba.2016.04.028

Biochemometrics for natural products research: Comparison of data analysis approaches and application to the identification of bioactive compounds.

Joshua J. Kellogg, Daniel A. Todd, Joseph M. Egan, Huzefa A. Raja, Nicholas H. Oberlies, Olav M. Kvalheim, Nadja B. Cech.

Journal of Natural Products, 2016, 79 (2), 376-86

PMID: 26841051, PMCID: PMC5135737, doi: 10.1021/acs.jnatprod.5b01014

Comparison of electrospray ionization and atmospheric pressure photoionization liquid chromatography mass spectrometry methods for analysis of ergot alkaloids from endophyte- infected sleepygrass (Achnatherum robustum).

Alan K. Jarmusch, Ashley M. Musso, Tatsiana Shymanovich, Scott A. Jarmusch, Mary Beth E. Lovin, Brandie M. Ehrmann, Susanna Saari, David E. Nichols, Stanley H. Faeth, Nadja B. Cech.

Journal of Pharmaceutical and Biomedical Analysis, 2016, 117, 11-17.

PMID: 26340558, doi: 10.1016/j.jpba.2015.08.031

Alkaloid variation among epichloid endophytes of sleepygrass (Achnatherum robustum) and consequences for resistance to insect herbivores.

Tatsiana Shymanovich, Susanna Saari, Mary E. Lovin, Alan K. Jarmusch, Scott A. Jarmusch, Ashleigh M. Musso, Nikki D. Charlton, Carolyn A. Young, Nadja B. Cech, Stanley H. Faeth.

Journal of Chemical Ecology, 2015, 41 (1), 93-104

PMID: 25501262, doi: 10.1007/s10886-014-0534-x

Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle).

Huzefa A. Raja, Amninder Kaur, Tamam El-Elimat, Mario Figueroa, Rahul Kumar, Gagan Deep, Rajesh Agarwal, Stanley H. Faeth, Nadja B. Cech, Nicholas H. Oberlies.

Mycology, 2015, 6 (1), 8-27

PMID: 26000195, PMCID: PMC4409047, doi: 10.1080/21501203.2015.1009186

A new mass spectrometry based bioassay for the direct assessment of hyaluronidase activity and inhibition.

Emily R. Britton, Carolyn B. Ibberson, Alexander R. Horswill, Nadja B. Cech.

Journal of Microbiological Methods, 119, 163-167.

PMID: 26519769, PMCID: PMC4663139, doi: 10.1016/j.mimet.2015.10.019

Cytokine-suppressive activity of a hydroxylated alkylamide from Echinacea purpurea.

Martha Leyte-Luge, Daniel A. Todd, Tyler V. Gulledge, Emily R. Britton, Monika Juzumaite, Fred S. Carter, Scott M. Laster, Nadja B. Cech.

Planta Medica Letters, 2015, 2 (01), e25-e27.

doi: 10.1055/s-0035-1557764

ω-Hydroxyemodin limits Staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.

Seth M. Daly, Barry O. Elmore, Jeffrey S. Kavanaugh, Kathleen D. Triplett, Mario Figueroa, Huzefa A. Raja, Tamam El-Elimat, Heidi A. Crosby, Jon K Femling, Nadja B. Cech, Alexander R. Horswill, Nicholas H. Oberlies, Pamela R. Hall.

Antimicrobial Agents and Chemotherapy, 2015, 59 (4), 2223-35.

PMID: 25645827, PMCID: PMC4356798, doi: 10.1128/AAC.04564-14

Ethanolic Echinacea purpurea extracts contain a mixture of cytokine-suppressive and cytokine-inducing compounds, including some that originate from endophytic bacteria.

Daniel A. Todd, Tyler V. Gulledge, Emily R. Britton, Martina Oberhofer, Martha Leyte-Lugo, Ashley A. Moody, Tatsiana Shymanovich, Laura F. Grubbs, Monika Juzumaite, Tyler N. Graf, Nicholas H. Oberlies, Stanley H. Faeth, Scott M. Laster, Nadja B. Cech.

Plos One, 2015, 10 (5), e0124276.

PMID: 25933416, PMCID: PMC4416932, doi: 10.1371/journal.pone.0124276

A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.

Adam R. Brown, Keivan A. Ettefagh, Daniel A. Todd, Patrick S. Cole, Joseph M. Egan, Daniel H. Foil, Tyler N. Graf, Bryan D. Schindler, Glen W. Kaatz, Nadja B. Cech.

Plos One, 10 (5), e0124814.

PMID: 25961825, PMCID: PMC4427306, doi: 10.1371/journal.pone.0124814

Comparison of the chemistry and diversity of endophytes isolated from wild-harvested and greenhouse-cultivated yerba mansa (Anemopsis californica).

R. Owen Bussey III, Amninder Kaur, Daniel A. Todd, Joseph M. Egan, Tamam El-Elimat, Tyler N. Graf, Huzefa A. Raja, Nicholas H. Oberlies, Nadja B. Cech.

Phytochemistry Letters, 2015, 11, 202-208

PMID: 25642298, PMCID: PMC4307022, doi: 10.1016/j.phytol.2014.12.013

Investigations of analyte-specific response saturation and dynamic range limitations in atmospheric pressure ionization mass spectrometry.

Clint Alfaro, Agbo-Oma Uwakweh, Daniel A. Todd, Brandie M. Ehrmann, Nadja B. Cech.

Analytical Chemistry, 2014, 86 (21), 10639-45.

PMID:25268329, doi: 10.1021/ac502984a

Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry.

Mario Figueroa, Alan K. Jarmusch, Huzefa A. Raja, Tamam El-Elimat, Jeffrey S. Kavanaugh, Alexander R. Horswill, R. Graham Cooks, Nadja B. Cech, Nicholas H. Oberlies.

Journal of Natural Products, 2014, 77 (6), 1351-8.

PMID:24911880, PMCID: PMC4073659, doi: 10.1021/np5000704

Staphylococcus epidermidis agr quorum-sensing system: Signal identification, cross talk, and importance in colonization.

Michael E. Olson, Daniel A. Todd, Carolyn R. Schaeffer, Alexandra E. Paharik, Michael J. Van Dyke, Henning Buttner, Paul M. Dunham, Holger Rohde, Nadja B. Cech, Paul D. Fey, Nadja B. Cech, Alexander R. Horswill.

Journal of Bacteriology, 2014, 196 (19), 3482-93.

PMID: 25070736, PMCID: PMC4187671, doi: 10.1128/JB.01882-14

Identification of morphological and chemical markers of dry- and wet-season conditions in female Anopheles gambiae mosquitoes.

Kaira M. Wagoner, Tovi Lehmann, Diana L. Huestis, Brandie M. Ehrmann, Nadja B. Cech, Gideon Wasserberg.

Parasites & Vectors, 2014, 7, 294.

PMID: 24970701, PMCID: PMC4099382, doi: 10.1186/1756-3305-7-294

Antimycobacterial furofuran lignans from the roots of Anemopsis californica.

R. Owen Bussey III, Arlene A. Sy-Cordero, Mario Figueroa, Fred S. Carter, Joseph O. Falkinham III, Nicholas H. Oberlies, Nadja B. Cech.

Planta Medica, 2014, 80 (6), 498-501.

PMID: 24687738, PMCID: PMC4586282, doi: 10.1055/s-0034-1368352

CodY-mediated regulation of the Staphylococcus aureus Agr system integrates nutritional and population density signals.

Agnès Roux, Daniel A. Todd, Jose V. Velázquez, Nadja B. Cech, and Abraham L. Sonenshein.

Journal of Bacteriology, 2014, 196 (6), 1184-96.

PMID: 24391052, PMCID: PMC3957711, doi: 10.1128/JB.00128-13

Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).

Tamam El-Elimat, Huzefa A. Raja, Tyler N. Graf, Stan H. Faeth, Nadja B. Cech, and Nicholas H. Oberlies.

Journal of Natural Products, 2014, 77 (2), 193-9.

PMID: 24456525, doi: 10.1021/np400955q

Small molecule quorum quenchers for prevention of Staphylococcus aureus infection.

Nadja B. Cech and Alexander R. Horswill.

Future Microbiology (editorial), 2013, 8 (12), 1511-4.

PMID:24266350, doi: 10.2217/fmb.13.134

Strategies and pitfalls in the application of mass spectrometry to natural products research.

Nadja B. Cech and Kate Yu.

LCGC North America, 31 (11), 938–947.

chromatographyonline

A high-resolution MS, MS/MS, and UV database of fungal secondary metabolites as a dereplication protocol for bioactive natural products.

Tamam El-Elimat, Mario Figueroa, Brandie M. Ehrmann, Nadja B. Cech, Cedric Pearce, Nicholas H. Oberlies.

Journal of Natural Products, 2013, 76 (9), 1709-16.

PMID: 23947912, PMCID: PMC3856222, doi: 10.1021/np4004307

Rapid quantitation of furanocoumarins and flavonoids in grapefruit juice using ultra performance liquid chromatography.

Karen M. Vandermolen, Nadja B. Cech, Mary F. Paine, Nicholas H. Oberlies.

Phytochemical Analysis, 2013, 24 (6), 654-60.

PMID: 23780830, PMCID: PMC3855432, doi: 10.1002/pca.2449

Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography – high resolving power mass spectrometry.

Hiyas A. Junio, Daniel A. Todd, Keivan A. Ettefagh, Brandie M. Ehrmann, Jeffrey S. Kavanaugh, Alexander H. Horswill, Nadja B. Cech.

Journal of Chromatography B, 2013, 930, 7-12.

PMID: 23703543, PMCID: PMC3717363, doi: 10.1016/j.jchromb.2013.04.019

Sarothrin from Alkanna orientalis is an antimicrobial agent and efflux pump inhibitor.

Jessica R. Bame, Tyler N. Graf, Hiyas A. Junio, R. Owen Bussey, Scott A. Jarmusch, Tamam El-Elimat, Joseph O. Falkinham, Nicholas H. Oberlies, Richard A. Cech, Nadja B. Cech.

Planta Medica, 2013, 79 (5), 327-9.

PMID: 23468310, PMCID: PMC4527991, doi: 10.1055/s-0032-1328259

Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA).

Nadja B. Cech, Hiyas A. Junio, Laynez W. Ackermann, Jeffrey S. Kavanaugh, Alexander H. Horswill.

Planta Medica, 2012, 78 (14), 1556-61.

PMID: 22814821, PMCID: PMC4527992, doi: 10.1055/s-0032-1315042

Maplexins, new α-glucosidase inhibitors from red maple (Acer rubrum) stems.

Chunpeng Wan, Tao Yuan, Vamsikrishna Kandhi, Nadja B. Cech, Mingyong Xie, Navindra P. Seeram.

Bioorganic and Medicinal Chemistry Letters, 2012, 22 (1), 597-600.

PMID:22079755, doi: 10.1002/chin.201221211

Phenolic glycosides from sugar maple (Acer saccharum) bark.

Tao Yuan, Chunpeng Wan, Antonio Gonzalez-Sarrias, Vamsikrishna Kandhi, Nadja B. Cech, Navindra P. Seeram.

Journal of Natural Products, 2011, 74 (11), 2472-6.

PMID: 22032697, doi: 10.1021/np200678n

Synergy directed fractionation of botanical medicines: A case study with goldenseal (Hydrastis canadensis).

Hiyas A. Junio, Arlene A. Sy-Cordero, Keivan A. Ettefagh, Johnna T. Burns, Kathryn T. Micko, Tyler N. Graf, Scott J. Richter, Robert E. Cannon, Nicholas H. Oberlies, Nadja B. Cech.

Journal of Natural Products, 2011, 74 (7), 1621-9.

PMID: 21661731, PMCID: PMC3142294, doi: 10.1021/np200336g

Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis).

Chad E. Cecil, Jeanine M. Davis, Nadja B. Cech, Scott M. Laster.

Intertational Immunopharmacology, 2011, 11 (11), 1706-14.

PMID: 21683808, doi: 10.1016/j.intimp.2011.06.002

Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition.

Keivan A. Ettefagh, Johnna T. Burns, Hiyas A. Junio, Glenn W. Kaatz, Nadja B. Cech.

Planta Medica, 2010, 77 (8), 835-40.

PMID: 21157683, PMCID: PMC3100400, doi: 10.1055/s-0030-1250606

Echinacea and its alkylamides: effects on the influenza A-induced secretion of cytokines, chemokines, and PGE from RAW 264.7 macrophage-like cells.

Nadja B. Cech, Vamsikrishna Kandhi, Jeanine M. Davis, Amy Hamilton, Dawn Eads, Scott M. Laster.

Intertational Immunopharmacology, 2010, 10 (10), 1268-78.

PMID: 20674883, doi: 10.1016/j.intimp.2010.07.009

Selectivity in electrospray ionization mass spectrometry.

Nadja B. Cech and Christie G. Enke.

in: Electrospray and MALDI Mass Spectrometry, Ed. Cole, R.B., 2nd Edition, 49-73.

A validated liquid chromatography/electrospray ionization-mass spectrometry (LC/ESI-MS) method for quantification of spilanthol in Spilanthes acmella (L.) Murr.

Stacy S. Bae, Brandie M. Ehrmann, Keivan A. Ettefagh, Nadja B. Cech.

Phytochemical Analysis, 2010, 21 (5), 438-43.

PMID: 20310072; doi: 10.1002/pca.1215

Comparison of alkylamide yield in ethanolic extracts prepared from fresh versus dry Echinacea purpurea utilizing HPLC-ESI-MS.

Kevin Spelman, Matthew Wetschler, Nadja B. Cech.

Journal of Pharmaceutical and Biomedical Analysis, 2009, 49 (5), 1141-9.

PMID: 19321283, PMCID: PMC2745817, doi: 10.1016/j.jpba.2009.02.011

Role for PPARγ in IL-2 inhibition in T cells by Echinacea-derived undeca-2E-ene-8,10-diynoic acid isobutylamide

Kevin Spelman, Katrina Liams-Hauser, Nadja B. Cech, Ethan Will Taylor, Nicholas Smirnoff, Cynthia A. Wenner.

International Immunopharmacology, 2009, 9 (11), 1260-4.

PMID:19712756; doi: 10.1016/j.intimp.2009.08.009

Relative importance of basicity in the gas phase and in solution for determining selectivity in electrospray ionization mass spectrometry.

Brandie M. Ehrmann, Trina Henriksen, Nadja B. Cech.

Journal of the American Society for Mass Spectrometry, 2008, 19 (5), 719-28.

PMID: 18325781; doi: 10.1016/j.jasms.2008.01.003

Changes in floral color and anthocyanin production in Plantago lanceolata in response to temperature.

Elizabeth A. Stiles, Nadja B. Cech, Stacy M. W. Dee, Elizabeth P. Lacey.

Physiologia Plantarum, 2007, 129, 756-765.

Effects of herbal products and their constituents on human cytochrome P450_2E1 activity

Gregory M. Raner, Sean Cornelius, Kamalika Moulick, Yingqing Wang, Ashley M. Mortenson, Jonathan Hill, Connell Cunningham, Nadja B. Cech.

Food and Chemical Toxicology, 2007, 45 (12), 2359-65.

PMID: 17658211, PMCID: PMC2955861, doi: 10.1016/j.fct.2007.06.012

Echinacea alkylamides inhibit interleukin-2 production by Jurkat human T cells.

Masa Sasagawa, Nadja B. Cech, Dean E. Gray, Gary W. Elmer, Cynthia A. Wenner.

International Immunopharmacology, 2006, 6 (7), 1214-21.

PMID:16714226, doi: 10.1016/j.intimp.2006.02.003

Liver enzyme-mediated oxidation of Echinacea purpurea alkylamides: Production of novel metabolites and changes in immunomodulatory activity.

Nadja B. Cech, Katrina Tutor, Bethany A. Doty, Kevin Spelman, Masa Sasagawa, Gregory M. Raner, Cynthia A. Wenner.

Planta Medica, 2006, 72 (15), 1372-7.

PMID: 17054047, doi: 10.1055/s-2006-951718

Electrospray ionization mass spectrometry: How and when it works.

Nadja B. Cech and Christie G. Enke.

Encyclopedia of Mass Spectrometry, 8, 171-180.

High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkylamides and caffeic acid derivatives from Echinacea purpurea extracts.

Nadja B. Cech, Maqueita S. Eleazer, Lawresa T. Shoffner, Amanda C. Davis, Mark R. Crosswhite, Ashley M. Mortenson.

Journal of Chromatography A, 2006, 1103 (2), 219-28.

PMID: 16298376, doi: 10.1016/j.chroma.2005.11.008

The relative influences of acidity and polarity on responsiveness of small organic molecules to analysis with negative ion electrospray ionization mass spectrometry (ESI-MS).

Trina Henriksen, Renee K. Juhler, Bo Svensmark, Nadja B. Cech.

Journal of the American Society for Mass Spectrometry, 2005, 16 (4), 446-55.

PMID: 15792713, doi: 10.1016/j.jasms.2004.11.021

Practical implications of some recent studies in electrospray ionization fundamentals.

Nadja B. Cech and Christie G. Enke.

Mass Spectrometry Reviews, 2001, 20 (6), 362-87.

PMID: 11997944, doi: 10.1002/mas.10008

Electrospray ionization detection of an inherently nonresponsive epoxide by peptide binding.

Nadja B. Cech, Jennifer R. Krone, Christie G. Enke.

Rapid Communications in Mass Spectrometry, 2001, 15 (13), 1040-4.

PMID: 11404839, doi: 10.1002/rcm.337

Predicting electrospray response from chromatographic retention time.

Nadja B. Cech, Jennifer R. Krone, Christie G. Enke.

Analytical Chemistry, 2001, 73 (2), 208-13.

PMID: 11199967, doi: 10.1021/ac0006019

The effect of affinity for charged droplet surfaces on the fraction of analyte charged in the electrospray process.

Nadja B. Cech and Christie G. Enke.

Analytical Chemistry, 2001, 73 (19), 4632-9.

PMID: 11605841, doi: 10.1021/ac001267j

Importance of Gas-Phase Proton Affinities in Determining the Electrospray Ionization Response for Analytes and Solvents.

Ma’an H. Amad, Nadja B. Cech, George S. Jackson, Christie G. Enke.

Journal of Mass Spectrometry, 2000, 35 (7), 784-9.

PMID: 10934432, doi: 10.1002/1096-9888(200007)35:7<784::AID-JMS17>3.0.CO;2-Q

Relating electrospray ionization response to non-polar character of small peptides.

Nadja B. Cech and Christie G. Enke.

Analytical Chemistry, 2000, 72 (13), 2717-23.

PMID: 10905298, doi: 10.1021/ac9914869

Electrospray ionization mass spectrometric analysis of blood for differentiation of species.

Edgard O. Espinoza, Nadja B. Cech, Kathy M. Gordon, Jessica Ekhoff, Mark A. Kirms.

Analytical Biochemistry, 1999, 268 (2), 252-61.

PMID: 10075815, doi: 10.1006/abio.1998.3048