Plant Cyclic Peptide Biosynthesis Paper Published!

Our paper on the biosynthesis of cyclopeptide alkaloids and related plant side chain cross-linked cyclopeptides is out now in Angewandte Chemie International Edition. We used bioinformatics and metabolomics to uncover a plant biosynthetic cassette responsible for these diverse cyclic peptides. We then applied these insights to find new natural products in Coffea arabica. Finally, we reconstituted the first enzyme activity for a split BURP peptide cyclase!

Lima, S. T.*, Ampolini, B. G.*, Underwood, E. B.*, Graf, T. N., Earp, C. E., Khedi, I. C., Pasquale, M. A., and Chekan, J. R. (2022) A Widely Distributed Biosynthetic Cassette Is Responsible for Diverse Plant Side Chain Cross-Linked Cyclopeptides. Angew. Chem. Int. Ed Engl. (doi: 10.1002/anie.202218082)



20 Dec 2022