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Posted on November 16, 2016
Date - November 16, 2016
Ph.D. Literature Seminar—751
Title: “Enantioselective Photocatalysis: A dual catalytic approach using chiral Lewis acids and photoredox catalysts”
Photocatalysis is an emerging field in organic synthesis. The benefit is the ability to perform chemical transformations that can produce complex molecules under mild conditions using visible light. Photochemical cycloadditions have been widely used, but a major challenge is to develop enantioselective methods. This literature review is going to cover reports by the Dr. Tehshik Yoon group of University of Wisconsin at Madison. The Yoon group has recently developed novel methods to preform photocatalytic enantioselective cyclization reactions. His methodological approach is to use dual catalysis which utilizes a Ru(bpy)2+ photoredox catalyst and a chiral Lewis acid to yield enantioenriched products. One paper covers an intermolecular [2+2] cycloaddition to form enantioenriched cyclobutanes by using the dual catalytic approach. The second paper is a report of an intermolecular [3+2] cycloadditions that forms a cyclopentane with high yields and high enantioselectivities.