News & Events
Dr. André Beauchemin
Posted on November 20, 2015
Date - November 20, 2015
Department of Chemistry and Biomolecular Sciences
University of Ottawa
“Reaction Development Using Temporary Intramolecularity and Amphoteric Isocyanates”
Most agrochemicals and pharmaceuticals contain nitrogen atoms in their structure, and C-N bond forming reactions account for approximately 15% of the reactions used in pharmaceutical R & D efforts. Our group has long been interested in metal-free amination reactions to rapidly assemble nitrogen heterocycles, amines and imines derivatives. The challenges met when targeting difficult intermolecular alkene hydroaminations have led to opportunities in two areas: 1) the use aldehydes as catalysts exploiting temporary intramolecularity to achieve difficult or impossible reactions; 2) the discovery of nitrogen-substituted isocyanates, a family of amphoteric isocyanates with little literature precedence and considerable untapped synthetic potential for the incorporation of the N-N-CO motif in bioactive molecules. Recent reaction development efforts exploiting these approaches will be presented.