News & Events

When

Date - October 18, 2019
1:00 pm - 2:00 pm

What

Research Associate Professor
Eshelman School of Pharmacy
University of North Carolina, Chapel Hill
Talk Title: Investigating HIV Pharmacology with Mass Spectrometry Imaging

Abstract:

Mass spectrometry imaging (MSI) has emerged as a powerful approach for visualizing the spatial distribution of chemical information within all manner of biological samples. The technique is well-suited to addressing fundamental questions of clinical pharmacology relevant to HIV prevention, treatment, and cure. I will discuss two ongoing projects that utilize infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI. First, we are developing a multimodal imaging approach to quantitatively evaluate antiretroviral proximity to virus and target cells within putative viral reservoir tissues. Second, we are piloting a new approach to non-invasively and rapidly assess patient adherence to therapy within the timeframe of a clinic visit based on longitudinal profiling of antiretrovirals in hair strands.