News & Events

When

Date - November 4, 2016
12:00 am

What

Senior Staff Scientist
Biological Sciences Division,
Pacific Northwest National Laboratory

“Pushing the Limit of MS Sensitivity Via Advanced ESI Source and Interface Technologies”

Abstract:

One of the most important performance characteristics of electrospray ionization mass spectrometry (ESI-MS) is its achievable sensitivity limit. For effective analyses of complex chemical and biological samples, the need for higher ESI-MS sensitivity is essentially open ended as any significant improvement of the sensitivity would allow effective measurements of lower abundance species otherwise undetectable. It is well known that the achievable ESI-MS sensitivity is largely determined by the ionization efficiency in the ESI source and the ion transmission efficiency through the ESI-MS interface. This presentation will focus on highlighting our continued effort in developing new ESI source and MS interface technologies aiming at resolving major challenges limiting both the ESI efficiency and the interface ion transmission efficiency. The implementation of these technologies on different mass spectrometers has made a major impact on the achievable MS sensitivity. The fundamental principles behind the development of these highly efficient technologies will also be discussed.