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Tyler Wilson

Posted on September 28, 2016


Date - September 28, 2016
1:00 pm


Ph.D. Literature Seminar – 751

Title: “Enantioselective Organocatalytic Cyclopropanation of Enals using Benzyl Chlorides.”


Cyclopropanes are found in many natural products and have been shown to have a wide array of biological activities for insecticidal, antibiotic, antifungal, antitumor, and antiviral purposes. As such, they have become a focus for asymmetric chemists to develop methodologies yielding enantioenriched cyclopropanes. This has been done from a variety of approaches using chiral auxiliaries, chiral transition-metal complexes and organocatalytic methods. The cyclopropanation of enals using benzyl chlorides through an organocatalytic pathway utilizing chiral secondary amines is reported producing excellent  stereoselectivity.