News & Events
Tyler Wilson
Posted on September 28, 2016
When
Date - September 28, 2016
1:00 pm
What
Ph.D. Literature Seminar – 751
Title: “Enantioselective Organocatalytic Cyclopropanation of Enals using Benzyl Chlorides.”
Abstract:
Cyclopropanes are found in many natural products and have been shown to have a wide array of biological activities for insecticidal, antibiotic, antifungal, antitumor, and antiviral purposes. As such, they have become a focus for asymmetric chemists to develop methodologies yielding enantioenriched cyclopropanes. This has been done from a variety of approaches using chiral auxiliaries, chiral transition-metal complexes and organocatalytic methods. The cyclopropanation of enals using benzyl chlorides through an organocatalytic pathway utilizing chiral secondary amines is reported producing excellent stereoselectivity.