News & Events

When

Date - November 5, 2021
1:00 pm - 2:00 pm

What

Assistant Professor
Department of Chemistry
University of North Carolina at Chapel Hill
Talk Title: Synthetic Methods Inspired by Complex Natural Products

Abstract:

Complex secondary metabolites isolated from natural sources (i.e. natural products) provide a wealth of diverse chemical space and often serve as the basis for drug development.  Furthermore, the synthesis of natural products serves to test current reaction methodologies in complex environments as well as provide inspiration for developing new reactions.  An active goal of the Hill group is to develop new reactions to access orphaned cyclopropanes, strained carbocycles that lack catalytic enantioselective methods for their synthesis. We are studying the use of a,a-disubstituted N-tosylhydrazones to accomplish this goal using Pd-catalyzed 3-exo-trig cyclizations as a keeps C–C bond forming step