News & Events

When

Date - September 20, 2023
1:00 pm - 2:00 pm

What

Literature Seminar
Department of Chemistry & Biochemistry
UNC Greensboro
Croatt Research Group

Talk Title:

“Advancements and Analysis in Copper-Free Cycloaddition Click Chemistry”

Abstract:

First introduced by Sharpless and Meldal in 2001, Click Chemistry has shown to prove a simple, yet complex reaction. 1,3-dipolar cycloaddition of an azide and alkyne click together to form triazoles in isomeric mixtures. Cu(I) has been useful for the rapid and selective conversion for 1,4-disubstitued triazoles. This has been implemented into pharmaceutical use and stereospecific control in synthetic reactions. Copper is cytotoxic to cells and can cause cells to go into a state of apoptosis. As one of the three Nobel Prize Laureates for 2022, Bertozzi discovered a simpler synthetic route to create difluoronated cyclooctynes (DIFO’s) for copper-free Click Chemistry. The advancements and analysis of this in-vivo study will be discussed.