News & Events

Leslie Hicks, Ph.D.

Posted on October 13, 2023


Date - October 13, 2023
1:00 pm - 2:00 pm


Sherman Fairchild Foundation Chancellor’s Science Scholar Term Associate Professor
Department of Chemistry
University of North Carolina Chapel Hill

Talk Title: “Plant-Derived Antimicrobial Peptide Discovery”


“While natural products are a well-studied source of biologically active small molecules, bioactive peptides contributing to their medicinal properties remain largely unexplored. To this end, we have developed the PepSAVI-MS pipeline to identify bioactive peptides from complex biological samples. PepSAVI-MS is highly versatile as it is adaptable to any natural product source and can test against diverse physiological targets (e.g. bacteria, fungi, and cancer cells) for which there is a developed bioassay. We demonstrate the power of this approach to probe an array of botanical natural product sources to prioritize highly active peptides for downstream analysis.”